Biophotonics
The Science Behind LuViva
Biophotonics is the science of harnessing light to image, detects and manipulate biological materials.
The LuViva® Advanced Cervical Scan, developed by Guided Therapeutics is based on the science of biophotonics. LuViva scans cervical tissue with light and detect chemical and structural changes at the cellular level. Unlike the Pap Smear, Liquid-based cytology or biopsy LuViva is designed to provide a result immediately after the scan with no waiting for laboratory reports.
Biophotonics
The Science Behind LuViva
Biophotonics is the science of harnessing light to image, detects and manipulate biological materials.
The LuViva® Advanced Cervical Scan, developed by Guided Therapeutics is based on the science of biophotonics. LuViva scans cervical tissue with light and detect chemical and structural changes at the cellular level. Unlike the Pap Smear, Liquid-based cytology or biopsy LuViva is designed to provide a result immediately after the scan with no waiting for laboratory reports.
Since the scanning technology can detect chemical and physical changes up to 5 mm below the surface, the disease may be detected before it reaches the surface and be detected by colposcopy.
Biophotonics can detect diseases before they become apparent on the surface.
Since the scanning technology can detect chemical and physical changes up to 5 mm below the surface, the disease may be detected before it reaches the surface and be detected by colposcopy.
Biophotonics can detect diseases before they become apparent on the surface.
The LuViva® Advanced Cervical Scan uses reflectance and fluorescence spectroscopy in vivo to detect both physical and chemical changes in the cervical tissue that are indicators of cervical cancer.
Reflectance
Reflectance spectroscopy measures the color and intensity of reflected light and can be used to determine if structural changes are taking place in tissue. In the case of LuViva, structural changes that effect light reflectance are: epithelial thickening, nuclear size and content and increased blood flow.
Fluorescence
Fluorescence spectroscopy measures the wavelength of light that is re-emitted from an object that has been illuminated. It is used to determine the presence and concentration of certain chemical markers present in tissue. In the case of LuViva, fluorescent markers present that may indicate the early stages of cancer are: tryptophan, flavins and/or collagen.
LuViva’s performance
in pivotal clinical trial
- May reduce unnecessary colposcopy and biopsies by as much as 40%
- Detected 36.4% more CIN2+ than tests used under current guidelines
- Detected disease up to 2 years earlier than Pap, HPV, and colposcopy
Source: Twiggs LB, Chakhtoura NA, Ferris DG, et al. Multimodal hyperspectroscopy as a triage test for cervical neoplasia: pivotal clinical trial results. Gynecol Oncol. 2013;130(1):147-151.
The LuViva® Advanced Cervical Scan uses reflectance and fluorescence spectroscopy in vivo to detect both physical and chemical changes in the cervical tissue that are indicators of cervical cancer.
Reflectance
Reflectance spectroscopy measures the color and intensity of reflected light and can be used to determine if structural changes are taking place in tissue. In the case of LuViva, structural changes that effect light reflectance are: epithelial thickening, nuclear size and content and increased blood flow.
Fluorescence
Fluorescence spectroscopy measures the wavelength of light that is re-emitted from an object that has been illuminated. It is used to determine the presence and concentration of certain chemical markers present in tissue. In the case of LuViva, fluorescent markers present that may indicate the early stages of cancer are: tryptophan, flavins and/or collagen.
LuViva’s performance
in pivotal clinical trial
- May reduce unnecessary colposcopy and biopsies by as much as 40%
- Detected 36.4% more CIN2+ than tests used under current guidelines
- Detected disease up to 2 years earlier than Pap, HPV, and colposcopy
Source: Twiggs LB, Chakhtoura NA, Ferris DG, et al. Multimodal hyperspectroscopy as a triage test for cervical neoplasia: pivotal clinical trial results. Gynecol Oncol. 2013;130(1):147-151.
indications for LuViva
LuViva is intended for use
on women aged 16+
- who have been referred for additional testing after abnormal cytology and/or positive HPV findings and/or other risk factors prior to colposcopy and biopsy
- as a primary screener when conventional screening tests are not as available.
indications for LuViva
LuViva is intended for use
on women aged 16+
- who have been referred for additional testing after abnormal cytology and/or positive HPV findings and/or other risk factors prior to colposcopy and biopsy
- as a primary screener when conventional screening tests are not as available.
publications
For more information regarding the clinical performance of LuViva®
Advanced Cervical Scan, please visit this page:
publications
For more information regarding the clinical performance of LuViva® Advanced Cervical Scan, please visit this page:
