Biophotonics
The Science
Behind LuViva
Biophotonics is the science of harnessing light to image, detects and manipulate biological materials.
The LuViva® Advanced Cervical Scan, developed by Guided Therapeutics is based on the science of biophotonics. LuViva scans cervical tissue with light and detect chemical and structural changes at the cellular level. Unlike the Pap Smear, Liquid-based cytology or biopsy LuViva is designed to provide a result immediately after the scan with no waiting for laboratory reports.
Biophotonics
The Science Behind LuViva
Biophotonics is the science of harnessing light to image, detects and manipulate biological materials.
The LuViva® Advanced Cervical Scan, developed by Guided Therapeutics is based on the science of biophotonics. LuViva scans cervical tissue with light and detect chemical and structural changes at the cellular level. Unlike the Pap Smear, Liquid-based cytology or biopsy LuViva is designed to provide a result immediately after the scan with no waiting for laboratory reports.
Since the scanning technology can detect chemical and physical changes up to 5 mm below the surface, the disease may be detected before it reaches the surface and be detected by colposcopy.
Biophotonics can detect diseases before they become apparent on the surface.
Since the scanning technology can detect chemical and physical changes up to 5 mm below the surface, the disease may be detected before it reaches the surface and be detected by colposcopy.
Biophotonics can detect diseases before they become apparent on the surface.
Spectroscopy is the study of the absorption and emission of light. The LuViva® Advanced Cervical Scan uses two types of spectroscopy, reflectance and fluorescence, to detect if the physical and chemical traits of cervical cancer are present in the cervix.
Reflectance
Reflectance spectroscopy measures the color and intensity of reflected light and can be used to determine if structural changes are taking place in tissue.
Fluorescence
Fluorescence spectroscopy measures the wavelength of light that is re-emitted from an object that has been illuminated.
Spectroscopy is the study of the absorption and emission of light. The LuViva® Advanced Cervical Scan uses two types of spectroscopy, reflectance and fluorescence, to detect if the physical and chemical traits of cervical cancer are present in the cervix.
Reflectance
Reflectance spectroscopy measures the color and intensity of reflected light and can be used to determine if structural changes are taking place in tissue.
Fluorescence
Fluorescence spectroscopy measures the wavelength of light that is re-emitted from an object that has been illuminated.
the scanning process
You will not feel any difference compared to a standard physical
examination at the gynecologist.
During this exam, your knees will be bent, your legs will be placed in stirrups and the physician will use a speculum to hold the vagina open while LuViva is scanning your cervix.
A single-use LuViva Cervical Guide will be inserted through the speculum until it touches your cervix.
Light will be painlessly shined onto your cervix and analyzed by the LuViva. The results will be displayed on the monitor for your physician to determine your next step in care.
The actual scanning time is 1 minute and 20 seconds. The scanning process is not painful, however, pressure from the speculum and Cervical Guide may be felt. Nothing is applied to the cervix and no tissue samples are taken, so there is little risk of irritation or light bleeding that can happen during a biopsy.
the scanning process
You will not feel any difference compared to a standard physical
examination at the gynecologist.
During this exam, your knees will be bent, your legs will be placed in stirrups and the physician will use a speculum to hold the vagina open while LuViva is scanning your cervix.
A single-use LuViva Cervical Guide will be inserted through the speculum until it touches your cervix.
Light will be painlessly shined onto your cervix and analyzed by the LuViva. The results will be displayed on the monitor for your physician to determine your next step in care.
The actual scanning time is 1 minute and 20 seconds. The scanning process is not painful, however, pressure from the speculum and Cervical Guide may be felt. Nothing is applied to the cervix and no tissue samples are taken, so there is little risk of irritation or light bleeding that can happen during a biopsy.
Luviva’s performance
in pivotal clinical trial
May reduce unnecessary colposcopy and biopsies by as much as 40%
Detected 36.4% more CIN2+ than tests used under current guidelines
Detected disease up to 2 years earlier than Pap, HPV, and colposcopy
Source: Twiggs LB, Chakhtoura NA, Ferris DG, et al. Multimodal hyperspectroscopy as a triage test for cervical neoplasia: pivotal clinical trial results. Gynecol Oncol. 2013;130(1):147-151.
Luviva’s performance
in pivotal clinical trial
May reduce unnecessary colposcopy and biopsies by as much as 40%
Detected 36.4% more CIN2+ than tests used under current guidelines
Detected disease up to 2 years earlier than Pap, HPV, and colposcopy
Source: Twiggs LB, Chakhtoura NA, Ferris DG, et al. Multimodal hyperspectroscopy as a triage test for cervical neoplasia: pivotal clinical trial results. Gynecol Oncol. 2013;130(1):147-151.
physicians’s reviews
Physicians who have used luviva advanced cervical scan
Leo B. Twiggs MD
Professor Emeritus
Department of Obstetrics and Gynecology
University of Miami
Miami, Florida, USA
„LuViva has shown the ability to reduce unnecessary procedures by 35–40%, thus significantly reducing health care expenditures in the field of cervical precancer and improving the patient’s experience.”
Source: Pub 2013 Is Colposcopy and-or Biopsy Always Necessary
Zoárd T. Krasznai MD
Associate Professor
Director of Obstetrics and Gynecology Clinic
University of Debrecen
Debrecen, Hungary
„In the case of cytological abnormality, the Multimodal Hyper Spectroscopy (MHS) provides an immediate result based on advanced digital technology, and because of its outstanding false negative rate it is a great aid and should be considered in the triage of such patients.”
Source: Pub 2021 MHS- The Use of Digital Technology in Cervical Cancer Screening
Daron G. Ferris MD
Professor
Department of Obstetrics and Gynecology
GRU Cancer Center
Augusta, Georgia, USA
„Use of Fluorescent and Reflective Spectroscopy (FRS) as a colposcopic adjunct was supported very favorably by women. Fewer women supported FRS replacing Pap smears. These high rates of approval by women should help the implementation of FRS technology.”
Source: Pub 2021 MHS- The Use of Digital Technology in Cervical Cancer Screening
Ömer Demir MD
Doctor of Medicine
Gynecology and Obstetrics Department
Istanbul Univerity
Istanbul, Turkey
„Scanning of the cervix by Multimodal Hyper Spectroscopy (MHS) may perform similar to Pap smear + HPV testing and may have a higher specificity in low-risk pregnant women.”
Source: Pub 2020 Performance of MHS for Scanning Cervix in Pregnant Women
physicians’s reviews
Physicians who have used luviva advanced cervical scan
Leo B. Twiggs MD
Professor Emeritus
Department of Obstetrics and Gynecology
University of Miami
Miami, Florida, USA
„LuViva has shown the ability to reduce unnecessary procedures by 35–40%, thus significantly reducing health care expenditures in the field of cervical precancer and improving the patient’s experience.”
Source: Pub 2013 Is Colposcopy and-or Biopsy Always Necessary
Zoárd T. Krasznai MD
Associate Professor
Director of Obstetrics and Gynecology Clinic
University of Debrecen
Debrecen, Hungary
„In the case of cytological abnormality, the Multimodal Hyper Spectroscopy (MHS) provides an immediate result based on advanced digital technology, and because of its outstanding false negative rate it is a great aid and should be considered in the triage of such patients.”
Source: Pub 2021 MHS- The Use of Digital Technology in Cervical Cancer Screening
Daron G. Ferris MD
Professor
Department of Obstetrics and Gynecology
GRU Cancer Center
Augusta, Georgia, USA
„Use of Fluorescent and Reflective Spectroscopy (FRS) as a colposcopic adjunct was supported very favorably by women. Fewer women supported FRS replacing Pap smears. These high rates of approval by women should help the implementation of FRS technology.”
Source: Pub 2021 MHS- The Use of Digital Technology in Cervical Cancer Screening
Ömer Demir MD
Doctor of Medicine
Gynecology and Obstetrics Department
Istanbul Univerity
Istanbul, Turkey
„Scanning of the cervix by Multimodal Hyper Spectroscopy (MHS) may perform similar to Pap smear + HPV testing and may have a higher specificity in low-risk pregnant women.”
Source: Pub 2020 Performance of MHS for Scanning Cervix in Pregnant Women
experience of women
who have tried biophotonics examination of the cervix*
More than 80% of women agree that they would rather have the new light test instead of a Pap smear.
85% of women wanted their doctor to have this new test.
87% of women asked would recommend biophotonics based screening to a friend.
Only 11% of women were bothered by the extra time required for the spectroscopic portion of their visit.
* Women’s Responses to Cervical Interrogation by Fluorescent and Reflective Spectroscopy Study – The Medical College of Georgia, Augusta, GA
experience of women
who have tried biophotonics examination of the cervix*
More than 80% of women agree that they would rather have the new light test instead of a Pap smear.
85% of women wanted their doctor to have this new test.
87% of women asked would recommend biophotonics based screening to a friend.
Only 11% of women were bothered by the extra time required for the spectroscopic portion of their visit.
* Women’s Responses to Cervical Interrogation by Fluorescent and Reflective Spectroscopy Study – The Medical College of Georgia, Augusta, GA
publications
Should you wish to know more about the clinical performance of
LuViva® Advanced Cervical Scan, please visit this page:
publications
Should you wish to know more about the clinical performance of LuViva® Advanced Cervical Scan, please visit this page:
FAQ
1. Will the LuViva scan hurt? (or What does a LuViva scan feel like?)
Most women find the LuViva exam comparable to a Pap test in comfort. While the Cervical Guide is in place you may feel pressure and cramping, these will go away when the Cervical Guide and speculum are removed. During the scan, you will not feel the light on your cervix.
2. How long does the scan take?
The time it takes to scan the entire cervix is approximately 1 minute and 20 seconds.
3. Is the light being shined on me harmful?
No. LuViva is compliant with all U.S. and international guidelines regarding exposure to light and it is like the light generated by a typical colposcope.
4. When will I get my results?
Your results will display on the device’s monitor immediately after the scan.
5. What will my physician do with the results/what do the results mean?
Depending on your result, your physician may send you home without the need for other procedures, recommend you return for an additional visit or testing, or perform additional examinations and/or tests while you are in the office.
6. Why should I get a LuViva test?
LuViva is the choice for women wanting new technology that provides information that may be different or more accurate than traditional tests such as the Pap test or colposcopy. Since the time between performing the test and getting its results occurs within a few minutes, it may also appeal to women who wish to find out sooner about their cervical health.
7. How does LuViva differ from a Pap or HPV test?
LuViva differs from the Pap smear/test and HPV in the way the test is administered and the information that the test provides to the healthcare worker and their patients. Using only light, LuViva scans the cervix to determine if the early physical and chemical signs of cervical cancer are present on and a few millimeters below surface of the cervix. The test doesn’t require applying or removing anything from the cervix and the result is provided immediately following the scan. Both the Pap smear/test and HPV test require a sample of surface cervical cells be sent to a lab to determine if there is an active HPV infection or, in the case of the Pap test, to see if the cervical cells show signs of potential cervical cancer.
FAQ
1. Will the LuViva scan hurt? (or What does a LuViva scan feel like?)
Most women find the LuViva exam comparable to a Pap test in comfort. While the Cervical Guide is in place you may feel pressure and cramping, these will go away when the Cervical Guide and speculum are removed. During the scan, you will not feel the light on your cervix.
2. How long does the scan take?
The time it takes to scan the entire cervix is approximately 1 minute and 20 seconds.
3. Is the light being shined on me harmful?
No. LuViva is compliant with all U.S. and international guidelines regarding exposure to light and it is like the light generated by a typical colposcope.
4. When will I get my results?
Your results will display on the device’s monitor immediately after the scan.
5. What will my physician do with the results/what do the results mean?
Depending on your result, your physician may send you home without the need for other procedures, recommend you return for an additional visit or testing, or perform additional examinations and/or tests while you are in the office.
6. Why should I get a LuViva test?
LuViva is the choice for women wanting new technology that provides information that may be different or more accurate than traditional tests such as the Pap test or colposcopy. Since the time between performing the test and getting its results occurs within a few minutes, it may also appeal to women who wish to find out sooner about their cervical health.
7. How does LuViva differ from a Pap or HPV test?
LuViva differs from the Pap smear/test and HPV in the way the test is administered and the information that the test provides to the healthcare worker and their patients. Using only light, LuViva scans the cervix to determine if the early physical and chemical signs of cervical cancer are present on and a few millimeters below surface of the cervix. The test doesn’t require applying or removing anything from the cervix and the result is provided immediately following the scan. Both the Pap smear/test and HPV test require a sample of surface cervical cells be sent to a lab to determine if there is an active HPV infection or, in the case of the Pap test, to see if the cervical cells show signs of potential cervical cancer.